The one-pot synthesis of a target molecule in the same reaction vessel is widely considered
to be an efficient approach in synthetic organic chemistry. In this review, the characteristics …

Conspectus We would all like to make or obtain the materials or products we want as soon
as possible. This is human nature. This is true also for chemists in the synthesis of organic …

We synthesized a new class of bifunctional catalysts bearing a thiourea moiety and an
amino group on a chiral scaffold. Among them, thiourea 1e bearing 3, 5-bis (trifluoromethyl) …

The existence of a receptor for γ-aminobutyric acid (GABA) on neurones of the mammalian
central nervous system (CNS) is now firmly established1–3. It is generally accepted that …

Several different drugs are now used, or are potentially useful, to treat patients with
spasticity. Although these compounds vary in their actions on spinal neurons and reflex arcs …

From a historical perspective, chemists have been most conversant with stereochemical
principles and the complex mixtures which occur when organic compounds, including drugs …

γ-Amino acids have attracted considerable attention as biologically active compounds in the
central nervous system (CNS) of mammals. Over the last few years, significant interest in the …

Publisher Summary This chapter focuses on the pharmacological properties of GABA B
receptors, the intracellular signaling systems to which these receptors are coupled, and their …

Abstract 1 Saturable binding of (+/-)-[3H]-baclofen and [3H]-gamma-aminobutyric acid ([3H]-
GABA) to rat brain crude synaptic membranes has been examined by means of a …

Baclofen has been used as an antispastic agent for over a decade1, yet its mechanism of
action is still not fully understood. While early iontophoretic studies revealed a depression of …