Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

Toxoplasma gondii is a ubiquitous parasitic protist found in a wide variety of hosts, including
a large proportion of the human population. Beyond an acute phase which is generally self …

Protein knockdown using the auxin-inducible degron (AID) technology is useful to study
protein function in living cells because it induces rapid depletion, which makes it possible to …

The auxin-inducible degron (AID) system has emerged as a powerful tool to conditionally
deplete proteins in a range of organisms and cell types. Here, we describe a toolkit to …

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …

The basal complex (BC) is essential for T. gondii cell division but mechanistic details are
lacking. Here we report a reciprocal proximity based biotinylation approach to map the BC's …

Members of Apicomplexa are defined by apical cytoskeletal structures and secretory
organelles, tailored for motility, invasion and egress. Gliding is powered by actomyosin …

Toxoplasma gondii has a complex life cycle that is typified by asexual development that
takes place in vertebrates, and sexual reproduction, which occurs exclusively in felids and is …

To survive and proliferate in diverse host environments with varying nutrient availability, the
obligate intracellular parasite Toxoplasma gondii reprograms its metabolism. We have …

Nucleophilic amino acids are important in covalent drug development yet underutilized as
anti-microbial targets. Chemoproteomic technologies have been developed to mine …