Declining thymic functions associated either with old age (ie, age-related thymic involution),
or with acute involution as a result of stress, infectious disease, or cytoreductive therapies …

The thymus, a primary lymphoid organ, produces the T cells of the immune system.
Originating from the 3 rd pharyngeal pouch during embryogenesis, this organ functions …

T cell development in the thymus is essential for cellular immunity and depends on the
organotypic thymic epithelial microenvironment. In comparison with other organs, the size …

Thymus is necessary for lifelong immunological tolerance and immunity. It displays a
distinctive epithelial complexity and undergoes age-dependent atrophy. Nonetheless, it also …

The thymus is the organ responsible for T cell development and the formation of the
adaptive immunity function. Its multicellular environment consists mainly of the different …

The thymus is a primary lymphoid organ essential for the induction of central immune
tolerance. Maturing T cells undergo several steps of expansion and selection mediated by …

Thymic epithelial cells (TECs) orchestrate T cell development by imposing positive and
negative selection on thymocytes. Current studies on TEC biology are hampered by the …

During embryonic development, several independent generations of hematopoietic cells
were identified. They occur in the yolk sac and the intra‐embryonic major arteries, in a …

Thymic epithelial cells (TECs) are important for T cell development and immune tolerance
establishment. Although comprehensive molecular regulation of TEC development has …

Epidemiologic data suggest that cancer survivors tend to develop a protuberant number of
adverse late effects, including second primary malignancies (SPM), as a result of cytotoxic …