The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

The renin–angiotensin system (RAS) plays a pivotal role in cardiovascular and hydro-
electrolyte homeostasis. Blockade of the RAS as a therapeutic strategy for treating …

Diminazene aceturate (DIZE), a putative angiotensin-converting enzyme 2 (ACE2) activator,
elicits relaxation in various animal models. This study aimed to determine the relaxing …

Angiotensin converting enzyme 2 (ACE2) plays beneficial roles in the renin angiotensin
aldosterone system. Our previous studies indicated that egg white-derived antihypertensive …

Neuroinflammation is associated with activation of glial cells and pro-inflammatory arm of
the central Renin Angiotensin System (RAS) namely, Angiotensin-Converting …

Abstract Diminazene aceturate (C 14 H 15 N 7. 2C 4 H 7 NO 3) is an aromatic diamidine that
was developed more than six decades ago and has been marketed until today for the …

Activation of ACE2 may represent an important therapeutic approach in cardiovascular
disease. To date, most studies have focused on the off-target actions of DIZE, in …

Abstract Angiotensin (Ang)-(1-7) is an active peptide formed from Ang I or Ang-(1-9) by
multiple proteolytic steps involving angiotensin-converting enzyme (ACE) 1 and other …

Background Apelin is an endogenous peptidergic system which modulates cardiovascular
function. Recent studies pointed out a fundamental contribution of apelin on atherosclerosis …

The renin-angiotensin-aldosterone system (RAAS) is more complex than it was originally
regarded. According to the current subject knowledge, there are two main axes of the …