Pathogenicity and virulence of Staphylococcus aureus

GYC Cheung, JS Bae, M Otto - Virulence, 2021 - Taylor & Francis
Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and
mortality due to an infectious agent. This pathogen can cause a wide variety of diseases …

Methicillin-resistant Staphylococcus aureus

AS Lee, H De Lencastre, J Garau… - Nature reviews Disease …, 2018 - nature.com
Since the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has emerged,
disseminated globally and become a leading cause of bacterial infections in both health …

Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms

JM Kwiecinski, AR Horswill - Current opinion in microbiology, 2020 - Elsevier
Highlights•Phagocytes play both protective and detrimental roles in containing bloodstream
S. aureus.•S. aureus hijacks the host coagulation system and uses it to bind host …

Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

J Clegg, E Soldaini, RM McLoughlin… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

X Wang, CD Thompson, C Weidenmaier… - Nature …, 2018 - nature.com
Secretion of extracellular vesicles (EVs), a process common to eukaryotes, archae, and
bacteria, represents a secretory pathway that allows cell-free intercellular communication …

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8

L Strauß, M Stegger, PE Akpaka… - Proceedings of the …, 2017 - National Acad Sciences
USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicillin-
resistant Staphylococcus aureus (CA-MRSA) with specific molecular characteristics. Despite …

Antimicrobial peptides and small molecules targeting the cell membrane of Staphylococcus aureus

N Ganesan, B Mishra, LO Felix… - … and Molecular Biology …, 2023 - Am Soc Microbiol
Clinical management of Staphylococcus aureus infections presents a challenge due to the
high incidence, considerable virulence, and emergence of drug resistance mechanisms …

Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages

JH Jiang, DR Cameron, C Nethercott… - Clinical microbiology …, 2023 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …

Antibody-based biologics and their promise to combat Staphylococcus aureus infections

WE Sause, PT Buckley, WR Strohl, AS Lynch… - Trends in …, 2016 - cell.com
The growing incidence of serious infections mediated by methicillin-resistant
Staphylococcus aureus (MRSA) strains poses a significant risk to public health. This risk is …