The multifaceted roles of NLRP3-modulating proteins in virus infection
The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
RNA helicase DDX3: a double-edged sword for viral replication and immune signaling
DDX3 is a cellular ATP-dependent RNA helicase involved in different aspects of RNA
metabolism ranging from transcription to translation and therefore, DDX3 participates in the …
metabolism ranging from transcription to translation and therefore, DDX3 participates in the …
Proteins from Tenebrio molitor: An interesting functional ingredient and a source of ACE inhibitory peptides
A Brai, CI Trivisani, C Vagaggini, R Stella, R Angeletti… - Food Chemistry, 2022 - Elsevier
The angiotensin-converting enzyme (ACE) inhibitory potential of the main protein fractions
from Tenebrio molitor larvae (TML) was examined to evaluate their use as a novel …
from Tenebrio molitor larvae (TML) was examined to evaluate their use as a novel …
Targeting DEAD‐box RNA helicases: The emergence of molecular staples
RNA helicases constitute a large family of proteins that play critical roles in mediating RNA
function. They have been implicated in all facets of gene expression pathways involving …
function. They have been implicated in all facets of gene expression pathways involving …
Progress towards adjuvant development: focus on antiviral therapy
In recent decades, vaccines have been extraordinary resources to prevent pathogen
diffusion and cancer. Even if they can be formed by a single antigen, the addition of one or …
diffusion and cancer. Even if they can be formed by a single antigen, the addition of one or …
DExD/H-box helicases in HIV-1 replication and their inhibition
Antiretroviral therapy (ART) reduces human immunodeficiency virus type 1 (HIV-1) infection,
but selection of treatment-refractory variants remains a major challenge. HIV-1 encodes 16 …
but selection of treatment-refractory variants remains a major challenge. HIV-1 encodes 16 …
Host DDX helicases as possible SARS-CoV-2 proviral factors: a structural overview of their hijacking through multiple viral proteins
F Squeglia, M Romano, A Ruggiero, G Maga… - Frontiers in …, 2020 - frontiersin.org
As intracellular parasites, viruses hijack the host cell metabolic machinery for their
replication. Among other cellular proteins, the DEAD-box (DDX) RNA helicases have been …
replication. Among other cellular proteins, the DEAD-box (DDX) RNA helicases have been …
Broad‐spectrum flavivirus inhibitors: a medicinal chemistry point of view
Infections by flaviviruses, such as Dengue, West Nile, Yellow Fever and Zika viruses,
represent a growing risk for global health. There are vaccines only for few flaviviruses while …
represent a growing risk for global health. There are vaccines only for few flaviviruses while …
[HTML][HTML] Piperazine-derived small molecules as potential Flaviviridae NS3 protease inhibitors. In vitro antiviral activity evaluation against Zika and Dengue viruses
M del Rosario García-Lozano, F Dragoni, P Gallego… - Bioorganic …, 2023 - Elsevier
Abstract Since 2011 Direct Acting antivirals (DAAs) drugs targeting different non-structural
(NS) viral proteins (NS3, NS5A or NS5B inhibitors) have been approved for clinical use in …
(NS) viral proteins (NS3, NS5A or NS5B inhibitors) have been approved for clinical use in …
Targeting host DEAD-box RNA helicase DDX3X for treating viral infections
PT Winnard Jr, F Vesuna, V Raman - Antiviral research, 2021 - Elsevier
Abstract DDX3X or DDX3, a member of the DEAD (asp, glu, ala, asp) box RNA helicase
family of proteins, is a multifunctional protein, which is usurped by several viruses and is vital …
family of proteins, is a multifunctional protein, which is usurped by several viruses and is vital …