Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets

Y Fu, X Wang, W Kong - British journal of pharmacology, 2018 - Wiley Online Library
Homocysteine is a sulphur‐containing non‐proteinogenic amino acid.
Hyperhomocysteinaemia (HHcy), the pathogenic elevation of plasma homocysteine as a …

Does folic acid protect patients with inflammatory bowel disease from complications?

AE Ratajczak, A Szymczak-Tomczak, AM Rychter… - Nutrients, 2021 - mdpi.com
Folic acid, referred to as vitamin B9, is a water-soluble substance, which participates in the
synthesis of nucleic acids, amino acids, and proteins. Similarly to B12 and B6, vitamin B9 is …

Folate-dependent hypermobility syndrome: A proposed mechanism and diagnosis

J Courseault, C Kingry, V Morrison, C Edstrom… - Heliyon, 2023 - cell.com
Hypermobility involves excessive flexibility and systemic manifestations of connective tissue
fragility. We propose a folate-dependent hypermobility syndrome model based on clinical …

Myocardial Infarction Following COVID-19 Vaccine Administration: Post Hoc, Ergo Propter Hoc?

A Baronti, F Gentile, AC Manetti, A Scatena… - Viruses, 2022 - mdpi.com
Vaccination against coronavirus disease 2019 (COVID-19) is the safest and most effective
strategy for controlling the pandemic. However, some cases of acute cardiac events …

Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia

M Xu, S Wu, Y Wang, Y Zhao, X Wang, C Wei… - Frontiers in …, 2022 - frontiersin.org
Methotrexate (MTX) is a folic acid antagonist, the mechanism of action is to inhibit DNA
synthesis, repair and cell proliferation by decreasing the activities of several folate …

Problem in the recent American Heart association guideline on secondary stroke prevention: B vitamins to lower homocysteine do prevent stroke

JD Spence, GJ Hankey - Stroke, 2022 - Am Heart Assoc
In this article, we discuss a problem in the most recent American Heart Association guideline
on secondary stroke prevention that apparently arose from the rules of evidence imposed on …

Genetic analyses of 104 phenotypes in 20,900 Chinese pregnant women reveal pregnancy-specific discoveries

H Xiao, L Li, M Yang, X Zhang, J Zhou, J Zeng, Y Zhou… - Cell Genomics, 2024 - cell.com
Monitoring biochemical phenotypes during pregnancy is vital for maternal and fetal health,
allowing early detection and management of pregnancy-related conditions to ensure safety …

Impact of MTHFR gene polymorphism on the outcome of methotrexate treatment in a sample of Iraqi rheumatoid arthritis patients

QM Mutlak, AA Kasim - Scientific Reports, 2024 - nature.com
Analyze the relationship between genetic variations in the MTHFR gene at SNPs
(rs1801131 and rs1801133) and the therapy outcomes for Iraqi patients with rheumatoid …

Associations of Maternal rs1801131 Genotype in MTHFR and Serum Folate and Vitamin B12 with Gestational Diabetes Mellitus in Chinese Pregnant Women

S Li, X Tian, Y Wang, X Zhang, L Zhang, C Li, J Li… - Nutrients, 2022 - mdpi.com
Circumstantial evidence links one-carbon metabolism (OCM) related nutrients, such as
folate and vitamin B12, with gestational diabetes mellitus (GDM). However, few studies have …

[PDF][PDF] Folate deficiency and gene polymorphisms of MTHFR, MTR and MTRR elevate the hyperhomocysteinemia risk

WX Li, F Cheng, AJ Zhang, SX Dai, GH Li, WW Lv… - Clin Lab, 2017 - researchgate.net
We aimed to investigate the joint effect of homocysteine metabolism gene polymorphisms,
as well as the folate deficiency on the risk of HHcy in a Chinese hypertensive population …