Large-vessel vasculitis (LVV) manifests as inflammation of the aorta and its major branches
and is the most common primary vasculitis in adults. LVV comprises two distinct conditions …

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely related conditions
characterized by systemic inflammation, a predominant IL-6 signature, an excellent …

Objectives Granulocyte-macrophage colony-stimulating factor (GM-CSF) is implicated in
pathogenesis of giant cell arteritis. We evaluated the efficacy of the GM-CSF receptor …

Th17/Treg imbalance is closely related to the occurrence and development of multiple
sclerosis (MS), and the transdifferentiation of Th17 cells into Treg cells may contribute to the …

The term “vasculitis” refers to a group of rare immune‐mediated diseases characterized by
the dysregulated immune system attacking blood vessels located in any organ of the body …

Vasculitis is an inflammation of the blood vessels caused by autoimmunity and/or
autoinflammation, and recent advances in research have led to a better understanding of its …

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

The giant cell arteritis (GCA) pathophysiology is complex and multifactorial, involving a
predisposing genetic background, the role of immune aging and the activation of vascular …

Giant cell arteritis (GCA) is the most common vasculitis among elderly people. The clinical
spectrum of the disease is heterogeneous, with a classic/cranial phenotype, and another …

Objective To identify the key coding genes underlying the biomarkers and pathways
associated with giant cell arteritis (GCA), we performed an in situ spatial profiling of …