Large-vessel vasculitis
D Pugh, M Karabayas, N Basu, MC Cid… - Nature Reviews …, 2021 - nature.com
Large-vessel vasculitis (LVV) manifests as inflammation of the aorta and its major branches
and is the most common primary vasculitis in adults. LVV comprises two distinct conditions …
and is the most common primary vasculitis in adults. LVV comprises two distinct conditions …
Disease stratification in GCA and PMR: state of the art and future perspectives
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely related conditions
characterized by systemic inflammation, a predominant IL-6 signature, an excellent …
characterized by systemic inflammation, a predominant IL-6 signature, an excellent …
Efficacy and safety of mavrilimumab in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial
MC Cid, SH Unizony, D Blockmans… - Annals of the …, 2022 - ard.bmj.com
Objectives Granulocyte-macrophage colony-stimulating factor (GM-CSF) is implicated in
pathogenesis of giant cell arteritis. We evaluated the efficacy of the GM-CSF receptor …
pathogenesis of giant cell arteritis. We evaluated the efficacy of the GM-CSF receptor …
Trojan horse nanocapsule enabled in situ modulation of the phenotypic conversion of Th17 cells to Treg cells for the treatment of multiple sclerosis in mice
C Shi, J Zhang, H Wang, C Chen, M Han… - Advanced …, 2023 - Wiley Online Library
Th17/Treg imbalance is closely related to the occurrence and development of multiple
sclerosis (MS), and the transdifferentiation of Th17 cells into Treg cells may contribute to the …
sclerosis (MS), and the transdifferentiation of Th17 cells into Treg cells may contribute to the …
The neutrophil: A key resourceful agent in immune‐mediated vasculitis
K Aymonnier, J Amsler, P Lamprecht… - Immunological …, 2023 - Wiley Online Library
The term “vasculitis” refers to a group of rare immune‐mediated diseases characterized by
the dysregulated immune system attacking blood vessels located in any organ of the body …
the dysregulated immune system attacking blood vessels located in any organ of the body …
[HTML][HTML] Perspectives of JAK inhibitors for large vessel vasculitis
R Watanabe, M Hashimoto - Frontiers in Immunology, 2022 - frontiersin.org
Vasculitis is an inflammation of the blood vessels caused by autoimmunity and/or
autoinflammation, and recent advances in research have led to a better understanding of its …
autoinflammation, and recent advances in research have led to a better understanding of its …
[HTML][HTML] Novel PET imaging of inflammatory targets and cells for the diagnosis and monitoring of giant cell arteritis and polymyalgia rheumatica
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …
[HTML][HTML] New insights into the pathogenesis of giant cell arteritis: mechanisms involved in maintaining vascular inflammation
H Greigert, C Genet, A Ramon, B Bonnotte… - Journal of Clinical …, 2022 - mdpi.com
The giant cell arteritis (GCA) pathophysiology is complex and multifactorial, involving a
predisposing genetic background, the role of immune aging and the activation of vascular …
predisposing genetic background, the role of immune aging and the activation of vascular …
[HTML][HTML] Advances in the treatment of giant cell arteritis
S Castañeda, D Prieto-Peña… - Journal of clinical …, 2022 - mdpi.com
Giant cell arteritis (GCA) is the most common vasculitis among elderly people. The clinical
spectrum of the disease is heterogeneous, with a classic/cranial phenotype, and another …
spectrum of the disease is heterogeneous, with a classic/cranial phenotype, and another …
[HTML][HTML] Use of high-plex data provides novel insights into the temporal artery processes of giant cell arteritis
Objective To identify the key coding genes underlying the biomarkers and pathways
associated with giant cell arteritis (GCA), we performed an in situ spatial profiling of …
associated with giant cell arteritis (GCA), we performed an in situ spatial profiling of …