Regulation of STAT3 signaling in IFNγ and IL10 pathways and in their cross-talk
The pro-inflammatory IFNγ-STAT1 pathway and anti-inflammatory IL10-STAT3 pathway elicit
cellular responses primarily utilizing their canonical STATs. However IL10 mediated STAT1 …
cellular responses primarily utilizing their canonical STATs. However IL10 mediated STAT1 …
Improving orthogonality in two-component biological signalling systems using feedback control
In natural biological systems, cellular responses to changing growth and environmental
conditions are governed by complex signalling and control networks. A common signalling …
conditions are governed by complex signalling and control networks. A common signalling …
Mitigating biological signalling cross-talk with feedback control
Biological signalling networks provide decision making and control capabilities for cells as
they interact with changing physiological and environmental conditions. Studies of these …
they interact with changing physiological and environmental conditions. Studies of these …
Quantitative modelling explains distinct STAT1 and STAT3 activation dynamics in response to both IFNγ and IL-10 stimuli and predicts emergence of reciprocal …
U Sarma, M Maitreye, S Bhadange, A Nair… - bioRxiv, 2018 - biorxiv.org
Cells use IFNγ-STAT1 and IL-10-STAT3 pathways primarily to elicit pro and anti-
inflammatory responses, respectively. However, activation of STAT1 by IL-10 and STAT3 by …
inflammatory responses, respectively. However, activation of STAT1 by IL-10 and STAT3 by …