The exocyst is an octameric protein complex that is implicated in the tethering of secretory
vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal …

Tethering factors have been shown to interact with Rabs and SNAREs and, more recently,
with coat proteins. Coat proteins are required for cargo selection and membrane …

Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for
generating cell diversity during development. The budding yeast Saccharomyces cerevisiae …

The exocyst complex is an evolutionarily conserved multisubunit protein complex implicated
in tethering secretory vesicles to the plasma membrane. Originally identified two decades …

Dynamin-related protein 1 (DRP1) plays an important role in mitochondrial fission at steady
state and during apoptosis. Using fluorescence recovery after photobleaching, we …

The exocyst is an octameric protein complex, which mediates the tethering of post-Golgi
secretory vesicles to the plasma membrane before exocytic fusion. The exocyst assembles …

Cell polarity relies on the asymmetric organization of cellular components and structures.
Actin and microtubules are well suited to provide the structural basis for cell polarization …

The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

Protein secretion is an essential process for living organisms. In eukaryotes, this
encompasses numerous steps mediated by several hundred cellular proteins. The core …

Intracellular trafficking entails the budding, transport, tethering, and fusion of transport
vesicles and other membrane carriers. Here we review recent progress toward a …