The evolving translational potential of small extracellular vesicles in cancer
Cancer-derived extracellular vesicles (EVs) are regarded as having promising potential to
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …
Diversity and biology of cancer-associated fibroblasts
G Biffi, DA Tuveson - Physiological reviews, 2020 - journals.physiology.org
Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …
compartment, despite the presence of non-neoplastic stromal components that substantially …
[HTML][HTML] Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression
E Yang, X Wang, Z Gong, M Yu, H Wu… - Signal transduction and …, 2020 - nature.com
Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …
[HTML][HTML] Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming
Z Li, C Sun, Z Qin - Theranostics, 2021 - ncbi.nlm.nih.gov
Cancer cells are well-known for adapting their metabolism to maintain high proliferation
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …
RNA-binding proteins contribute to small RNA loading in plant extracellular vesicles
Plants use extracellular vesicles (EVs) to transport small RNAs (sRNAs) into their fungal
pathogens and silence fungal virulence-related genes through a phenomenon called 'cross …
pathogens and silence fungal virulence-related genes through a phenomenon called 'cross …
Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities
D Hu, Z Li, B Zheng, X Lin, Y Pan, P Gong… - Cancer …, 2022 - Wiley Online Library
The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …
[HTML][HTML] Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts
C Zhang, XY Wang, P Zhang, TC He, JH Han… - Cell death & …, 2022 - nature.com
Tumor metastasis is a hallmark of cancer. The communication between cancer-derived
exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche …
exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche …
[HTML][HTML] Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells
X Yuan, N Qian, S Ling, Y Li, W Sun, J Li, R Du… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Breast cancer preferentially develops osteolytic bone metastasis, which makes
patients suffer from pain, fractures and spinal cord compression. Accumulating evidences …
patients suffer from pain, fractures and spinal cord compression. Accumulating evidences …
[HTML][HTML] Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma
Background & Aims Intrahepatic cholangiocarcinoma (ICC) is the second most common liver
malignancy. ICC typically features remarkable cellular heterogeneity and a dense stromal …
malignancy. ICC typically features remarkable cellular heterogeneity and a dense stromal …
[HTML][HTML] Extracellular vesicles as tools and targets in therapy for diseases
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …