Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility
Unlike other chromatin remodelers, INO80 preferentially mobilizes hexasomes, which can
form during transcription. Why INO80 prefers hexasomes over nucleosomes remains …
form during transcription. Why INO80 prefers hexasomes over nucleosomes remains …
[HTML][HTML] Spatial and temporal organization of chromatin at small and large scales
H Schiessel - Annual Review of Condensed Matter Physics, 2023 - annualreviews.org
DNA molecules with a total length of two meters contain the genetic information in every cell
in our body. To control access to the genes, to organize its spatial structure in the nucleus …
in our body. To control access to the genes, to organize its spatial structure in the nucleus …
Structural basis of telomeric nucleosome recognition by shelterin factor TRF1
Shelterin and nucleosomes are the key players that organize mammalian chromosome ends
into the protective telomere caps. However, how they interact with each other at telomeres …
into the protective telomere caps. However, how they interact with each other at telomeres …
Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
The cancer-specific fusion oncoprotein SS18–SSX1 disturbs chromatin accessibility by
hijacking the BAF complex from the promoters and enhancers to the Polycomb-repressed …
hijacking the BAF complex from the promoters and enhancers to the Polycomb-repressed …
Structural mechanism of extranucleosomal DNA readout by the INO80 complex
F Kunert, FJ Metzner, J Jung, M Höpfler, S Woike… - Science …, 2022 - science.org
The nucleosomal landscape of chromatin depends on the concerted action of chromatin
remodelers. The INO80 remodeler specifically places nucleosomes at the boundary of gene …
remodelers. The INO80 remodeler specifically places nucleosomes at the boundary of gene …
[HTML][HTML] Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex
In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the
activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the …
activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the …
Bi-directional nucleosome sliding by the Chd1 chromatin remodeler integrates intrinsic sequence-dependent and ATP-dependent nucleosome positioning
Chromatin remodelers use a helicase-type ATPase motor to shift DNA around the histone
core. Although not directly reading out the DNA sequence, some chromatin remodelers …
core. Although not directly reading out the DNA sequence, some chromatin remodelers …
Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1
S Woike, S Eustermann, J Jung, SJ Wenzl… - Nature structural & …, 2023 - nature.com
Abstract The Swi2/Snf2 family transcription regulator Modifier of Transcription 1 (Mot1) uses
adenosine triphosphate (ATP) to dissociate and reallocate the TATA box-binding protein …
adenosine triphosphate (ATP) to dissociate and reallocate the TATA box-binding protein …
The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder
K Cermakova, V Veverka… - Biochemical Society …, 2023 - portlandpress.com
Interaction scaffolds that selectively recognize disordered protein strongly shape protein
interactomes. An important scaffold of this type that contributes to transcription is the TFIIS N …
interactomes. An important scaffold of this type that contributes to transcription is the TFIIS N …