Anthropogenic global shifts in biospheric N and P concentrations and ratios and their impacts on biodiversity, ecosystem productivity, food security, and human health

J Penuelas, IA Janssens, P Ciais… - Global Change …, 2020 - Wiley Online Library
The availability of carbon (C) from high levels of atmospheric carbon dioxide (CO2) and
anthropogenic release of nitrogen (N) is increasing, but these increases are not paralleled …

Phosphate as a signaling molecule and its sensing mechanism

T Michigami, M Kawai, M Yamazaki… - Physiological …, 2018 - journals.physiology.org
In mammals, phosphate balance is maintained by influx and efflux via the intestines,
kidneys, bone, and soft tissue, which involves multiple sodium/phosphate (Na+/Pi) …

[HTML][HTML] High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III

AR Chang, M Lazo, LJ Appel, OM Gutierrez… - The American journal of …, 2014 - Elsevier
Background: Elevated serum phosphorus is associated with all-cause mortality, but little is
known about risk associated with dietary phosphorus intake. Objective: We investigated the …

Phosphate toxicity and tumorigenesis

RB Brown, MS Razzaque - Biochimica et Biophysica Acta (BBA)-Reviews …, 2018 - Elsevier
In this article, we briefly summarized evidence that cellular phosphate burden from
phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells …

[HTML][HTML] Human-driven global nutrient imbalances increase risks to health

J Penuelas, J Sardans - Eco-Environment & Health, 2023 - Elsevier
Human-induced inputs of nitrogen (N) and phosphorus (P) into the biosphere have reached
unprecedented levels, particularly N, leading to an escalating global anthropogenic N: P …

Serum lactate dehydrogenase and survival following cancer diagnosis

W Wulaningsih, L Holmberg, H Garmo… - British journal of …, 2015 - nature.com
Background: There is evidence that high level of serum lactate dehydrogenase (LDH) is
associated with poorer overall survival in several malignancies, but its link to cancer-specific …

Genetically predicted circulating concentrations of micronutrients and risk of breast cancer: a Mendelian randomization study

N Papadimitriou, N Dimou, D Gill… - … journal of cancer, 2021 - Wiley Online Library
The epidemiological literature reports inconsistent associations between consumption or
circulating concentrations of micronutrients and breast cancer risk. We investigated …

Role of fibroblast growth factor 23 (FGF23) and αKlotho in cancer

F Ewendt, M Feger, M Föller - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Together with fibroblast growth factors (FGFs) 19 and 21, FGF23 is an endocrine member of
the family of FGFs. Mainly secreted by bone cells, FGF23 acts as a hormone on the kidney …

Breast cancer, alcohol, and phosphate toxicity

RB Brown, P Bigelow, JA Dubin… - Journal of Applied …, 2024 - Wiley Online Library
Alcohol consumption is associated with an increased risk of breast cancer, even at low
alcohol intake levels, but public awareness of the breast cancer risk associated with alcohol …

[HTML][HTML] Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study

A Yiu, M Van Hemelrijck, H Garmo, L Holmberg… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Objectives Serum uric acid has been suggested to be associated with cancer risk. We aimed
to study the association between serum uric acid and cancer incidence in a large Swedish …