Oxygen-centered free radicals cause brain injury associated with trauma and stroke. These
reactive oxygen species may be detoxified by endogenous antioxidants, but cell death …

Cytochrome P450 enzymes (CYPs) metabolize many drugs that act on the central nervous
system (CNS), such as antidepressants and antipsychotics; drugs of abuse; endogenous …

General anesthesia (GA) is a reversible drug-induced state of altered arousal required for
more than 60,000 surgical procedures each day in the United States alone. Sedation and …

Propofol (2, 6-diisopropylphenol) has been shown to attenuate neuronal injury under a
number of experimental conditions; however, the mechanisms involved in its …

Background Propofol (2, 6-diisopropylphenol) has been shown to attenuate neuronal injury
in a number of experimental conditions, but studies in models of cerebral ischemia have …

1 The effects of five structurally dissimilar general anaesthetics were examined in voltage‐
clamp recordings of agonist‐evoked currents mediated by recombinant γ‐aminobutyric acid …

Background Many anesthetic agents are known to enhance the alpha1beta2gamma2S
gamma-aminobutyric acid type A (GABAA) chloride current; however, they also depress …

Background Propofol exerts protective effects on neuronal cells, in part through the inhibition
of programmed cell death. Autophagic cell death is a type of programmed cell death that …

Background During cerebral ischemia, excess of glutamate release and dysfunction of its
high affinity transport induce an accumulation of extracellular glutamate, which plays an …

Background Previous electrophysiologic studies have implicated voltage-dependent Na+
channels as a molecular site of action for propofol. This study considered the effects of …