SARS-CoV-2 spike S2-specific neutralizing antibodies

CJ Li, SC Chang - Emerging Microbes & Infections, 2023 - Taylor & Francis
Since the onset of the coronavirus disease 2019 (COVID-19), numerous neutralizing
antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation

H Nguyen, HL Nguyen, PD Lan, NQ Thai… - Chemical Society …, 2023 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Molnupiravir maintains antiviral activity against SARS-CoV-2 variants and exhibits a high barrier to the development of resistance

JM Strizki, JM Gaspar, JA Howe… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Molnupiravir, an oral prodrug of N-hydroxycytidine (NHC), previously demonstrated broad in
vitro antiviral activity against multiple RNA viruses and has shown a high barrier to the …

Protein aggregation rate depends on mechanical stability of fibrillar structure

TTM Thu, MS Li - The Journal of Chemical Physics, 2022 - pubs.aip.org
The formation of the fibrillar structure of amyloid proteins/peptides is believed to be
associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's …

Fast prediction of binding affinities of SARS-CoV-2 spike protein and its mutants with antibodies through intermolecular interaction modeling-based machine learning

AH Williams, CG Zhan - The Journal of Physical Chemistry B, 2022 - ACS Publications
Since the introduction of the novel SARS-CoV-2 virus (COVID-19) in late 2019, various new
variants have appeared with mutations that confer resistance to the vaccines and …

Current status and perspectives of therapeutic antibodies targeting the spike protein S2 subunit against SARS-CoV-2

Y Yamamoto, T Inoue - Biological and Pharmaceutical Bulletin, 2024 - jstage.jst.go.jp
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has devastated public health and the …

Neutralizing antibodies and their cocktails against SARS-CoV-2 Omicron and other circulating variants

Y Yang, L Du - Cellular & Molecular Immunology, 2022 - nature.com
Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus
disease 2019 (COVID-19), has led to a pandemic with severe economic losses. The viral …

[HTML][HTML] Antibody drugs targeting SARS-CoV-2: Time for a rethink?

L Liang, B Wang, Q Zhang, S Zhang, S Zhang - Biomedicine & …, 2024 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) heavily burdens human health. Multiple …

Structure adaptation in Omicron SARS-CoV-2/hACE2: Biophysical origins of evolutionary driving forces

YW Hsiao, DJ Bray, T Taddese, G Jiménez-Serratos… - Biophysical …, 2023 - cell.com
Since its emergence, the COVID-19 threat has been sustained by a series of transmission
waves initiated by new variants of the SARS-CoV-2 virus. Some of these arise with higher …

Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2

PD Lan, DA Nissley, EP O'Brien, TT Nguyen… - The Journal of Chemical …, 2024 - pubs.aip.org
The binding of the receptor binding domain (RBD) of the SARS-CoV-2 spike protein to the
host cell receptor angiotensin-converting enzyme 2 (ACE2) is the first step in human viral …