Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

Biological energy transduction underlies all physiological phenomena in cells. The
metabolic systems that support energy transduction have been of great interest due to their …

It is generally thought that under basal conditions, neurons produce ATP mainly through
mitochondrial oxidative phosphorylation (OXPHOS), and glycolytic activity only …

Although metastasis remains the cause of most cancer-related mortality, mechanisms
governing seeding in distal tissues are poorly understood. Here, we establish a robust …

CD8+ T cells undergo major metabolic changes upon activation, but how metabolism
influences the establishment of long-lived memory T cells after infection remains a key …

Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated.
Usually, it is the ability of the mitochondria to make ATP appropriately in response to energy …

Breakthrough technologies to measure cellular oxygen consumption and proton efflux are
reigniting the study of cellular energetics by increasing the scope and pace with which …

Fluorescent probes for monitoring mitochondrial membrane potential are frequently used for
assessing mitochondrial function, particularly in the context of cell fate determination in …

Autophagy is a catabolic pathway used by cells to support metabolism in response to
starvation and to clear damaged proteins and organelles in response to stress. We report …

Clearance or control of pathogens or tumors usually requires T‐cell‐mediated immunity. As
such, understanding the mechanisms that govern the function, maintenance, and …