The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …

Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response
(UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and …

Extensive research in the past decade has identified innate immune recognition receptors
and intracellular signaling pathways that culminate in inflammatory responses. Besides its …

The response to stress triggers activation of the genes involved in cell survival and/or cell
death. Stress response is a ubiquitous feature of cells that is induced under stress …

Due to its multiple features, including the ability to orchestrate remote communication
between different tissues, the exosomes are the extracellular vesicles arousing the highest …

Hsp60 is a chaperone belonging to the Chaperonins of Group I and typically functions inside
mitochondria in which, together with the co-chaperonin Hsp10, maintains protein …

Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their
rapid and abundant induction by stress. HSP genes are activated at the transcriptional level …

The metastasizing capacity of the rat pancreatic adenocarcinoma BSp73ASML (ASML wt) is
strikingly reduced by a knockdown of CD44v4-v7 (ASML kd). We used this model to analyze …