Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

A multifunctional magnetic red blood cell-mimetic micromotor for drug delivery and image-guided therapy

K Hou, Y Zhang, M Bao, C Xin, Z Wei… - ACS applied materials …, 2022 - ACS Publications
Inspired by nature, innovative devices have been made to imitate the morphology and
functions of natural red blood cells (RBCs). Here, we report a red blood cell-mimetic …

LipoCEST and cellCEST imaging agents: opportunities and challenges

G Ferrauto, D Delli Castelli… - Wiley …, 2016 - Wiley Online Library
From the early days of CEST agents' disclosure, it was evident that their potential for in vivo
applications was strongly hampered by the intrinsic low sensitivity. Therefore, much work …

CEST‐MRI for glioma pH quantification in mouse model: Validation by immunohistochemistry

G Ferrauto, E Di Gregorio, V Auboiroux… - NMR in …, 2018 - Wiley Online Library
In glioma, the acidification of the extracellular tumor microenvironment drives proliferation,
angiogenesis, immunosuppression, invasion and chemoresistance. Therefore …

Biomimetic surface modification of discoidal polymeric particles

TDT Nguyen, S Aryal, A Pitchaimani, S Park… - … , Biology and Medicine, 2019 - Elsevier
The rationale for the design of drug delivery nanoparticles is traditionally based on co-
solvent self-assembly following bottom-up approaches or in combination with top-down …

Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis

SG Crich, E Terreno, S Aime - Advanced Drug Delivery Reviews, 2017 - Elsevier
Abstract Magnetic Resonance Imaging (MRI) enables to provide anatomical, functional and
molecular information of pathological angiogenesis when used with properly tailored …

An MRI Method To Map Tumor Hypoxia Using Red Blood Cells Loaded with a pO2-Responsive Gd-Agent

E Di Gregorio, G Ferrauto, E Gianolio, S Lanzardo… - ACS …, 2015 - ACS Publications
Hypoxia is a typical hallmark of many solid tumors and often leads to therapy resistance and
the development of a more aggressive cancer phenotype. Oxygen content in tissues has …

Segmentation techniques for early cancer detection in red blood cells with deep learning‐based classifier—a comparative approach

JS Shemona, AK Chellappan - IET Image Processing, 2020 - Wiley Online Library
Red Blood Corpuscles called Erythrocytes are the most important element in blood
composition which is mainly responsible in all living cells. To detect the cancer cell various …

Ferucarbotran-loaded Red Blood Cells As Long Circulating MRI Contrast Agents: First In Vivo Results in Mice

A Antonelli, S Pacifico, C Sfara, M Tamma… - Nanomedicine, 2018 - Taylor & Francis
Aim: The encapsulation of superparamagnetic iron oxide contrast agents in red blood cells
(RBCs) could overcome their rapid removal by reticulo–endothelial system improving their …

Gadolinium retention in erythrocytes and leukocytes from human and murine blood upon treatment with gadolinium-based contrast agents for magnetic resonance …

E Di Gregorio, C Furlan, S Atlante… - Investigative …, 2020 - journals.lww.com
Objectives Being administered intravenously, the tissue that gadolinium-based contrast
agents (GBCAs) for magnetic resonance imaging mostly encounter is blood. Herein, it has …