The COVID-19 pandemic poses a significant challenge for individuals with compromised
immune systems, such as patients with cancer, as they face a heightened susceptibility to …

Besides its canonical role in protecting the host from pathogens, the immune system plays
an arguably equally important role in maintaining tissue homeostasis. Within barrier tissues …

Objective Subsets of CD21−/low memory B cells (MBCs), including double‐negative (DN,
CD27− IgD−) and Tbet+ CD11c+ cells, are expanded in chronic inflammatory diseases. In …

Immunosenescence increases the risk and severity of diseases in elderly individuals and
leads to impaired vaccine-induced immunity. With aging of the global population and the …

Background A definition of the immunological features of COVID-19 pneumonia is needed to
support clinical management of aged patients. In this study, we characterized the humoral …

Introduction B cells play a pivotal role in adaptive immunity which has been extensively
characterised primarily via flow cytometry-based gating strategies. This study addresses the …

Introduction Chronic immunopathology contributes to the development of heart failure after a
myocardial infarction. Both T and B cells of the adaptive immune system are present in the …

Idiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune
disorders characterized by progressive muscle weakness and the histopathologic findings of …

Cancer and aging are inextricably linked conditions. However, whether cancer emerges as
a byproduct of the aging process or whether aged cells themselves are prone to become …

Vaccination has been shown to be the most effective means of preventing infectious
diseases, although older people commonly have a suboptimal immune response to …