Brain circuits for pain and its treatment
Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
Role of the prefrontal cortex in pain processing
WY Ong, CS Stohler, DR Herr - Molecular neurobiology, 2019 - Springer
The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …
processing. The latter is dependent on its connections to other areas of the cerebral …
First-in-human prediction of chronic pain state using intracranial neural biomarkers
Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …
and disability. Pain severity is often measured through subjective report, while objective …
A neuronal circuit for activating descending modulation of neuropathic pain
J Huang, VM Gadotti, L Chen, IA Souza, S Huang… - Nature …, 2019 - nature.com
Neuropathic pain can be a debilitating condition with both sensory and affective
components, the underlying brain circuitry of which remains poorly understood. In the …
components, the underlying brain circuitry of which remains poorly understood. In the …
[HTML][HTML] Cellular circuits in the brain and their modulation in acute and chronic pain
Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
Neocortical circuits in pain and pain relief
LL Tan, R Kuner - Nature Reviews Neuroscience, 2021 - nature.com
The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …
incoming noxious inputs to generate variable pain perceptions. Technological advances in …
The mesolimbic dopamine system in chronic pain and associated affective comorbidities
RA Serafini, KD Pryce, V Zachariou - Biological psychiatry, 2020 - Elsevier
Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …
and affective symptoms. Over the past 2 decades, researchers have made significant …
Corticolimbic anatomical characteristics predetermine risk for chronic pain
Abstract See Tracey (doi: 10.1093/brain/aww147) for a scientific commentary on this article.
Mechanisms of chronic pain remain poorly understood. We tracked brain properties in …
Mechanisms of chronic pain remain poorly understood. We tracked brain properties in …
Neural mechanisms underlying anxiety–chronic pain interactions
M Zhuo - Trends in neurosciences, 2016 - cell.com
Chronic pain is a major medical problem that is resistant to conventional medical
intervention. It also causes emotional changes such as anxiety and fear. Furthermore …
intervention. It also causes emotional changes such as anxiety and fear. Furthermore …
Toward a unified framework for interpreting machine-learning models in neuroimaging
Abstract Machine learning is a powerful tool for creating computational models relating brain
function to behavior, and its use is becoming widespread in neuroscience. However, these …
function to behavior, and its use is becoming widespread in neuroscience. However, these …