Diabetes Mellitus, Mitochondrial Dysfunction and Ca2+-Dependent Permeability Transition Pore

KN Belosludtsev, NV Belosludtseva… - International journal of …, 2020 - mdpi.com
Diabetes mellitus is one of the most common metabolic diseases in the developed world,
and is associated either with the impaired secretion of insulin or with the resistance of cells …

The mitochondrial permeability transition: nexus of aging, disease and longevity

H Rottenberg, JB Hoek - Cells, 2021 - mdpi.com
The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

Targeting the mitochondrial permeability transition pore for drug discovery: Challenges and opportunities

ID Boyenle, AK Oyedele, AT Ogunlana, AF Adeyemo… - Mitochondrion, 2022 - Elsevier
Several drug targets have been amenable to drug discovery pursuit not until the
characterization of the mitochondrial permeability transition pore (MPTP), a pore with an …

TRAP1 chaperones the metabolic switch in cancer

LA Wengert, SJ Backe, D Bourboulia, M Mollapour… - Biomolecules, 2022 - mdpi.com
Mitochondrial function is dependent on molecular chaperones, primarily due to their
necessity in the formation of respiratory complexes and clearance of misfolded proteins …

Cyclophilin D regulation of the mitochondrial permeability transition pore

E Murphy - Current opinion in physiology, 2022 - Elsevier
The opening of the mitochondrial permeability transition pore (PTP) has been proposed to
play a critical role in activating cell death in many settings, including cardiac ischemia and …

[HTML][HTML] Amyloid β, α-synuclein and the c subunit of the ATP synthase: Can these peptides reveal an amyloidogenic pathway of the permeability transition pore?

GF Amodeo, EV Pavlov - Biochimica et Biophysica Acta (BBA) …, 2021 - Elsevier
Abstract Mitochondrial Permeability Transition (PT) is a phenomenon of increased
permeability of the inner mitochondrial membrane in response to high levels of Ca 2+ and/or …

[PDF][PDF] The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity. Cells 2021, 10, 79

H Rottenberg, JB Hoek - 2021 - pdfs.semanticscholar.org
The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

[引用][C] The new vision of mitochondrial permeability transition pore opening

EA Kasumov, RE Kasumov… - World Journal …, 2023 - World Journal of Advanced …

[引用][C] TRABAJO FIN DE GRADO TÍTULO: Dianas terapéuticas basadas en el metabolismo mitocondrial para el tratamiento de infarto e ictus

JP Yerpes - 2020 - UNIVERSIDAD COMPLUTENSE

[引用][C] BBA-Biomembranes

GF Amodeo, EV Pavlov