The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …

The recent advent of human pluripotent stem cell (PSC)-derived 3D brain organoids has
opened a window into aspects of human brain development that were not accessible before …

The brain extracellular space (ECS) is a vast interstitial reticulum of extreme morphological
complexity, composed of narrow gaps separated by local expansions, enabling …

Intracortical microelectrodes are a critical component of brain-machine interface (BMI)
systems. The recording performance of intracortical microelectrodes used for both basic …

The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …

Abstract Brain-Machine Interface systems (BMIs) are clinically valuable devices that can
provide functional restoration for patients with spinal cord injury or improved integration for …

The extracellular matrix is a richly bioactive composition of substrates that provides
biophysical stability, facilitates intercellular signaling, and both reflects and governs the …

Myelin is an essential structure that protects axons, provides metabolic support to neurons
and allows fast nerve transmission. Several neurological diseases, such as multiple …

The brain extracellular matrix (ECM) consists of extremely long-lived proteins that assemble
around neurons and synapses, to stabilize them. The ECM is thought to change only rarely …