The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …

Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …

DNA methylation represents a fundamental epigenetic mark that is associated with
transcriptional repression during development, maintenance of homeostasis, and disease …

The field of molecular biology is advancing fast with new powerful technologies, sequencing
methods and analysis software being developed constantly. Commonly used tools originally …

Fragments of cell-free DNA (cfDNA) in human body fluids often carry disease-specific
alterations and are now widely recognized as ideal biomarkers for the detection and …

Early diagnosis of cancer improves the efficacy of curative therapies. However, due to the
difficulties involved in distinguishing between small early-stage tumors and normal …

In plants, 5mC DNA methylation is an important and conserved epistatic mark involving
genomic stability, gene transcriptional regulation, developmental regulation, abiotic stress …

Whole-genome bisulfite sequencing (WGBS) is the standard method for profiling DNA
methylation at single-nucleotide resolution. Different tools have been developed to extract …

DNA methylation is a crucial epigenetic modification involved in multiple biological
processes and diseases. Current approaches for measuring genome-wide DNA methylation …

Advances in chromatin state mapping, high-throughput DNA sequencing, and bioinformatics
have revolutionized the study and interpretability of epigenomic variation. The increasing …