Developmental origins of metabolic diseases
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …
as obese, while nearly one-third of children globally experience poor growth and …
[HTML][HTML] The role of arachidonic and linoleic acid derivatives in pathological pregnancies and the human reproduction process
M Szczuko, J Kikut, N Komorniak, J Bilicki… - International journal of …, 2020 - mdpi.com
The aim of the available literature review was to focus on the role of the proinflammatory
mediators of AA and LA derivatives in pathological conditions related to reproduction and …
mediators of AA and LA derivatives in pathological conditions related to reproduction and …
SIRT3 deficiency is resistant to autophagy‐dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels
D Han, L Jiang, X Gu, S Huang, J Pang… - Journal of cellular …, 2020 - Wiley Online Library
Ferroptosis, an autophagy‐dependent cell death, is characterized by lipid peroxidation and
iron accumulation, closely associated with pathogenesis of gestational diabetes mellitus …
iron accumulation, closely associated with pathogenesis of gestational diabetes mellitus …
Uptake, transport, and toxicity of pristine and weathered micro-and nanoplastics in human placenta cells
HM Dusza, EA Katrukha, SM Nijmeijer… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: The first evidence of micro-and nanoplastic (MNP) exposure in the human
placenta is emerging. However, the toxicokinetics and toxicity of MNPs in the placenta …
placenta is emerging. However, the toxicokinetics and toxicity of MNPs in the placenta …
[HTML][HTML] TFEB controls syncytiotrophoblast formation and hormone production in placenta
M Cesana, G Tufano, F Panariello, N Zampelli… - Cell Death & …, 2024 - nature.com
TFEB, a bHLH-leucine zipper transcription factor belonging to the MiT/TFE family, globally
modulates cell metabolism by regulating autophagy and lysosomal functions. Remarkably …
modulates cell metabolism by regulating autophagy and lysosomal functions. Remarkably …
[HTML][HTML] Characterizing the brain structural adaptations across the motherhood transition
M Martínez-García, M Paternina-Die… - Frontiers in Global …, 2021 - frontiersin.org
Women that become mothers face notable physiological adaptations during this life-period.
Neuroimaging studies of the last decade have provided grounded evidence that women's …
Neuroimaging studies of the last decade have provided grounded evidence that women's …
[HTML][HTML] Early prediction and longitudinal modeling of preeclampsia from multiomics
Preeclampsia is a complex disease of pregnancy whose physiopathology remains unclear.
We developed machine-learning models for early prediction of preeclampsia (first 16 weeks …
We developed machine-learning models for early prediction of preeclampsia (first 16 weeks …
Biosynthesis of estetrol in human pregnancy: potential pathways
FZ Stanczyk, DF Archer - The Journal of Steroid Biochemistry and …, 2023 - Elsevier
Estetrol (E 4) has emerged as a novel and highly promising estrogen for therapeutic use. E 4
is a weak natural estrogen produced only in pregnancy. Because of its novelty, there is …
is a weak natural estrogen produced only in pregnancy. Because of its novelty, there is …
[HTML][HTML] Maternal urinary bisphenols and phthalates in relation to estimated fetal weight across mid to late pregnancy
W Cowell, MH Jacobson, SE Long, Y Wang… - Environment …, 2023 - Elsevier
Background Bisphenols and phthalates are high production volume chemicals used as
additives in a variety of plastic consumer products leading to near ubiquitous human …
additives in a variety of plastic consumer products leading to near ubiquitous human …
[HTML][HTML] P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss
C Ge, D Xu, P Yu, M Fang, J Guo, D Xu, Y Qiao… - BMC medicine, 2021 - Springer
Background Prenatal adverse environments can cause fetal intrauterine growth retardation
(IUGR) and higher susceptibility to multiple diseases after birth, related to multi-organ …
(IUGR) and higher susceptibility to multiple diseases after birth, related to multi-organ …