Individuals vary in their initial reactions to drugs of abuse in ways that may contribute to the
likelihood of subsequent drug use. In humans, most drugs of abuse produce positive …

Acetaldehyde has long been suggested to be involved in a number of ethanol's
pharmacological and behavioral effects, such as its reinforcing, aversive, sedative, amnesic …

Sardinian alcohol‐preferring (sP) and‐non‐preferring (sNP) rats are one of the pairs of rat
lines selectively bred for high and low alcohol preference and consumption, respectively …

The purpose of this review paper is to present evidence that rat animal models of alcoholism
provide an ideal platform for developing and screening medications that target alcohol …

Ethanol non‐drinker (UChA) and drinker (UChB) rat lines derived from an original Wistar
colony have been selectively bred at the University of Chile for over 70 generations. Two …

Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied
in the 1940s, but then research interest in this compound waned. However, in the last two …

If people are brought into the laboratory and given alcohol, there are pronounced
differences among individuals in many responses to the drug. Some participants in alcohol …

Animal models have been successfully developed to mimic and study alcoholism. These
models have the unique feature of allowing the researcher to control for the genetic …

Alcohol use disorder (AUD) is a complex, chronic, relapsing disorder with multiple
interacting genetic and environmental influences. Numerous studies have verified the …

Since the first experimental demonstration that a drug of abuse supports instrumental
behavior, drugs have been discussed in the context of their rewarding effects, which are …