The lineage transition between epithelium and mesenchyme is a process known as
epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their …

The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the …

Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …

Reprogramming somatic cells into pluripotent embryonic stem cells (ESCs) by somatic cell
nuclear transfer (SCNT) has been envisioned as an approach for generating patient …

The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) offers an
opportunity to generate pluripotent patient-specific cell lines that can help model human …

The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic
cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human …

Mitochondrial DNA mutations transmitted maternally within the oocyte cytoplasm often cause
life-threatening disorders. Here we explore the use of nuclear genome transfer between …

CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into
macrophages at high efficiencies and enhances reprogramming into induced pluripotent …

Human embryonic stem cells (hESCs) are a promising source of cells for tissue
regeneration, yet histoincompatibility remains a major challenge to their clinical application …

The transfer of somatic cell nuclei into oocytes can give rise to pluripotent stem cells that are
consistently equivalent to embryonic stem cells,,, holding promise for autologous cell …