Advances in structural biology and the exponential increase in the amount of high-quality
experimental structural data available in the Protein Data Bank has motivated numerous …

iCn3D was initially developed as a web-based 3D molecular viewer. It then evolved from
visualization into a full-featured interactive structural analysis software. It became a …

Antibodies and other new antibody-like formats have emerged as one of the most rapidly
growing classes of biotherapeutic proteins. Understanding the structural features that drive …

Chimeric Antigen Receptor T-cell (CAR-T) immunotherapies are dependent upon designed
transmembrane proteins to bind target antigens and stimulate an immune response. The …

ABSTRACT The Immunoglobulin fold (Ig-fold) is found in proteins from all domains of life
and represents the most populous fold in the human genome, with current estimates ranging …

Understanding the ancestral Ig domain's molecular structure and tracing the evolution of Ig-
like proteins are fundamental components missing from our comprehension of their …

The immunoglobulin fold (Ig fold) domain is a super-secondary structural motif consisting of
a sandwich with two layers of β-sheets that is present in many proteins with very diverse …