Dynamic regulation and functions of mRNA m6A modification
S Wang, W Lv, T Li, S Zhang, H Wang, X Li… - Cancer cell …, 2022 - Springer
Abstract N 6-Methyladenosine (m6A), the most abundant internal modification associated
with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the …
with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the …
[HTML][HTML] Role of m6A modification in female infertility and reproductive system diseases
J Chen, Y Fang, Y Xu, H Sun - International Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Gamete abnormalities and reproductive system tumors have become a dominant cause of
infertility, troubling people globally. In recent years, increasing evidence emerged and found …
infertility, troubling people globally. In recent years, increasing evidence emerged and found …
[HTML][HTML] METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection
N Li, H Hui, B Bray, GM Gonzalez, M Zeller… - Cell reports, 2021 - cell.com
It is urgent and important to understand the relationship of the widespread severe acute
respiratory syndrome coronavirus clade 2 (SARS-CoV-2) with host immune response and …
respiratory syndrome coronavirus clade 2 (SARS-CoV-2) with host immune response and …
Multiplexed profiling facilitates robust m6A quantification at site, gene and sample resolution
D Dierks, MA Garcia-Campos, A Uzonyi, M Safra… - Nature …, 2021 - nature.com
Abstract N 6-methyladenosine (m6A) is the most prevalent modification of messenger RNA
in mammals. To interrogate its functions and dynamics, there is a critical need to quantify …
in mammals. To interrogate its functions and dynamics, there is a critical need to quantify …
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication
HM Burgess, DP Depledge, L Thompson… - Genes & …, 2021 - genesdev.cshlp.org
Abstract N 6-methyladenosine (m 6 A) is an abundant internal RNA modification, influencing
transcript fate and function in uninfected and virus-infected cells. Installation of m 6 A by the …
transcript fate and function in uninfected and virus-infected cells. Installation of m 6 A by the …
[HTML][HTML] Anything but ordinary–emerging splicing mechanisms in eukaryotic gene regulation
NH Gehring, JY Roignant - Trends in Genetics, 2021 - cell.com
Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …
expression. The identification of the actual splice sites and the proper removal of introns are …
Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing
Adenovirus is a nuclear replicating DNA virus reliant on host RNA processing machinery.
Processing and metabolism of cellular RNAs can be regulated by METTL3, which catalyzes …
Processing and metabolism of cellular RNAs can be regulated by METTL3, which catalyzes …
Limits in the detection of m6A changes using MeRIP/m6A-seq
Many cellular mRNAs contain the modified base m6A, and recent studies have suggested
that various stimuli can lead to changes in m6A. The most common method to map m6A and …
that various stimuli can lead to changes in m6A. The most common method to map m6A and …
The m6A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis
Excessive cytokine activity underlies many autoimmune conditions, particularly through the
interleukin-17 (IL-17) and tumor necrosis factor–α (TNFα) signaling axis. Both cytokines …
interleukin-17 (IL-17) and tumor necrosis factor–α (TNFα) signaling axis. Both cytokines …
Dance with the devil: stress granules and signaling in antiviral responses
N Eiermann, K Haneke, Z Sun, G Stoecklin, A Ruggieri - Viruses, 2020 - mdpi.com
Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …