ABSTRACT Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that
plays a central role in limiting host immune response to pathogens, thereby preventing …

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …

Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …

The liver has vital metabolic and clearance functions that involve the uptake of nutrients,
waste products and pathogens from the blood. In addition, its unique immunoregulatory …

The liver is a unique anatomical and immunological site in which antigen‐rich blood from
the gastrointestinal tract is pressed through a network of sinusoids and scanned by antigen …

More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease …

Persistent viral infections are a major health concern. One obstacle inhibiting the clearance
of persistent infections is functional inactivation of antiviral T cells. Although such …

Viral replication and microbial translocation from the gut to the blood during HIV infection
lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers …

Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been
made in our understanding of its life cycle and interaction with the host immune system …

The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …