▪ Abstract The phytohemagglutinin-induced virus-inhibitor may, however, be produced in
white cells in response to a stimulation of cellular RNA synthesis and may be a feedback …

Abstract Indoleamine 2, 3-dioxygenase (IDO) is an enzyme that degrades the essential
amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell …

We have recently shown that expression of the enzyme indoleamine 2, 3-dioxygenase (IDO)
during murine pregnancy is required to prevent rejection of the allogeneic fetus by maternal …

Toxoplasma gondii can infect homoeothermic animals including humans and cause lethal
toxoplasmosis in immunocompromised individuals. When hosts are infected with T. gondii …

One mechanism contributing to immunologic unresponsiveness toward tumors may be
presentation of tumor antigens by tolerogenic host APCs. We show that mouse tumor …

Hosts have been fighting pathogens throughout the evolution of all infectious diseases.
Toxoplasma gondii is one of the most common infectious agents in humans but causes only …

Tryptophan (Trp) is an essential amino acid primarily derived from the diet for use by the
host for protein synthesis. The intestinal tract is lined with cells, both host and microbial, that …

A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to
convert from an acute disease-causing, proliferative stage (tachyzoite), to a chronic, dormant …

Tumorigenesis is a complex multifactorial and multistep process in which tumors can utilize
a diverse repertoire of immunosuppressive mechanisms to evade host immune attacks. The …

The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host
cell that manipulate the immune response allowing it to establish a chronic infection …