A series of N, N '-disubstituted ureas having a conformationally restricted cis-or trans-1, 4-
cyclohexane α to the urea were prepared and tested as soluble epoxide hydrolase (sEH) …

The development of new methods for regio‐and stereoselective activation of C− O bonds in
ethers holds significant promise for synthetic chemistry, offering advantages in terms of …

An anti-El ion channel antibody or binding fragment thereof, pharmaceutical compositions
comprising said antibodies, use of the antibodies and compositions comprising the same, in …

Glyburide (GLB) is a widely used oral sulfonylurea for the treatment of gestational diabetes.
The therapeutic use of GLB is often complicated by a substantial inter‐individual variability …

One of the factors affecting the pharmacokinetics (PK) of a drug during pregnancy is the
activity of hepatic and placental metabolizing enzymes. Recently, we reported on the …

Lycium barbarum polysaccharide (LBP) has been shown to have hypoglycemic and
antioxidative properties, although its mode of action is yet unknown. Because oxidative …

The estrogen receptors have played important roles in breast cancer development and
progression. Selective estrogen receptor modulators, such as Tamoxifen, have showed …

This report describes the development and validation of an LC‐MS/MS method for the
quantitative determination of glyburide (GLB), its five metabolites (M1, M2a, M2b, M3 and …

ATP-binding cassette (ABC) transporters are involved in a variety of physiological processes
such as lipid metabolism, ion homeostasis and immune functions. A large number of these …

The estrogen receptor α is recognized as important pharmaceutical target for breast cancer
therapy, and vascular endothelial growth factor receptors (VEGFRs) play important roles in …