The transcription factors p53 and NFκB determine cellular fate and are involved in the
pathogenesis of most–if not all–cancers. The crosstalk between these transcription factors …

The identification of the link between breast cancer and estrogens has led to the
development of antiestrogens, in particular tamoxifen, to inhibit the activities of estrogen …

The behavioral sensitization produced by repeated cocaine treatment represents the neural
adaptations underlying some of the features of addiction in humans. Cocaine …

Many co-regulator proteins are recruited by DNA-bound transcription factors to remodel
chromatin and activate transcription. However, mechanisms for coordinating actions of …

We recently showed that histone H2A. Z, as well as members of the ATP-dependent p400
chromatin remodeling complex (p400. com), are essential components of estrogen receptor …

Estrogen receptor α (ERα) is a modular protein of the steroid/nuclear receptor family of
transcriptional regulators that upon binding to the hormone undergoes structural changes …

Gadd45a (growth arrest and DNA-damage-inducible protein 45 alpha) plays a pivotal role in
cellular stress responses and is implicated in DNA repair, cell cycle arrest and apoptosis …

In non-malignant RWPE-1 prostate epithelial cells signaling by the nuclear receptor Vitamin
D Receptor (VDR, NR1I1) induces cell cycle arrest through targets including CDKN1A …

Psychostimulant-induced addiction involves potentially life-long behavioral abnormalities
that are caused by repeated exposure to a drug of abuse in vulnerable individuals. The …

Methylation and demethylation of cytosine residues in the genomic DNA play key roles in a
wide range of fundamental biological processes such as differentiation and development …