Despite being the second least represented granulocyte subpopulation in the circulating
blood, eosinophils are receiving a growing interest from the scientific community, due to their …

CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …

Blood platelets have long been recognised to bring about primary haemostasis with
deficiencies in platelet production and function manifesting in bleeding while upregulated …

Platelets are inflammatory anuclear cells with a well-established role in the development
and manifestation of atherosclerosis. Activated platelets secrete a plethora of chemokines …

The Hemostatic System as a Modulator of Atherosclerosis | NEJM Skip to main content NEJM
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Ample evidence exists in support of the potent anti-inflammatory properties of statins. In cell
studies and animal models statins exert beneficial cardiovascular effects. By inhibiting …

Reactive oxygen species (ROS) are generated within activated platelets and play an
important role in regulating platelet responses to collagen and collagen-mediated thrombus …

Platelets have evolved highly specialized adhesion mechanisms that enable cell-matrix and
cell-cell interactions throughout the entire vasculature irrespective of the prevailing …

Central obesity is independently associated with an elevated risk of cardiovascular disease,
particularly thrombotic complications. Increasing data supports a link between excess body …

The terms microparticles (MPs) and microvesicles (MVs) refer to large extracellular vesicles
(EVs) generated from a broad spectrum of cells upon its activation or death by apoptosis …