Principles and methods for transferring polygenic risk scores across global populations

L Kachuri, N Chatterjee, J Hirbo, DJ Schaid… - Nature Reviews …, 2024 - nature.com
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …

The Lancet and Financial Times Commission on governing health futures 2030: growing up in a digital world

I Kickbusch, D Piselli, A Agrawal, R Balicer, O Banner… - The Lancet, 2021 - thelancet.com
Executive summary From the short-term and long-term effects of the COVID-19 pandemic to
the health insecurities brought about by climate change, health futures are unfolding in an …

Stroke in Africa: profile, progress, prospects and priorities

RO Akinyemi, B Ovbiagele, OA Adeniji… - Nature Reviews …, 2021 - nature.com
Stroke is a leading cause of disability, dementia and death worldwide. Approximately 70% of
deaths from stroke and 87% of stroke-related disability occur in low-income and middle …

Emerging digital PCR technology in precision medicine

L Zhang, R Parvin, Q Fan, F Ye - Biosensors and Bioelectronics, 2022 - Elsevier
Digital PCR (dPCR) is built on partitioning reagent to the extent that single template
molecules are amplified and visualized individually, whereby offers higher precision and …

Five steps to make MRI scanners more affordable to the world

A Webb, J Obungoloch - Nature, 2023 - nature.com
Fifty years since the basis of magnetic resonance imaging was published, MRI scanners
remain expensive—and impractical in many countries. Here's how we are making them …

Clinical utility of whole-genome sequencing in precision oncology

R Rosenquist, E Cuppen, R Buettner, C Caldas… - Seminars in Cancer …, 2022 - Elsevier
Precision diagnostics is one of the two pillars of precision medicine. Sequencing efforts in
the past decade have firmly established cancer as a primarily genetically driven disease …

What's fair is… fair? Presenting JustEFAB, an ethical framework for operationalizing medical ethics and social justice in the integration of clinical machine learning …

M Mccradden, O Odusi, S Joshi, I Akrout… - Proceedings of the …, 2023 - dl.acm.org
The problem of algorithmic bias represents an ethical threat to the fair treatment of patients
when their care involves machine learning (ML) models informing clinical decision-making …

The WHO genomics program of work for equitable implementation of human genomics for global health

E Ambrosino, AN Abou Tayoun, M Abramowicz… - Nature Medicine, 2024 - nature.com
The publication of the first draft of the human genome sequence in 2001 1 was followed by
the advent of high-throughput methodologies, which together have driven the expansion of …

Stroke genetics: discovery, insight into mechanisms, and clinical perspectives

S Debette, HS Markus - Circulation Research, 2022 - Am Heart Assoc
Stroke is the second leading cause of death worldwide and a complex, heterogeneous
condition. In this review, we provide an overview of the current knowledge on monogenic …

Building causal knowledge in behavior genetics

JW Madole, KP Harden - Behavioral and Brain Sciences, 2023 - cambridge.org
Behavior genetics is a controversial science. For decades, scholars have sought to
understand the role of heredity in human behavior and life-course outcomes. Recently …