Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

The nuclear genome decays as organisms age. Numerous studies demonstrate that the
burden of several classes of DNA lesions is greater in older mammals than in young …

RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …

Aging is a continuous process over time that is mainly related to natural alterations in
mechanical–biological processes. This phenomenon is due to several factors, including the …

RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …

Pathway choice within DNA double-strand break (DSB) repair is a tightly regulated process
to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome …

Intron retention (IR) is the least well‐understood alternative splicing type in animals, and its
prevalence and function in physiological and pathological processes have long been …

Rothmund-Thomson syndrome (RTS) is an autosomal-recessive disorder characterized by
poikiloderma, sparse hair, short stature, and skeletal anomalies. Type 2 RTS, which is …

Lamin A-related progeroid syndromes are genetically determined, extremely rare and
severe. In the past ten years, our knowledge and perspectives for these diseases has widely …