Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Small synthetic molecules called growth hormone secretagogues (GHSs) stimulate the
release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G protein …

The recently discovered orexigenic peptide ghrelin is produced primarily by the stomach
and circulates in blood at levels that increase during prolonged fasting in rats. When …

Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue
receptor. It is synthesized predominantly in the stomach and found in the circulation of …

The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via
hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized …

The central melanocortin system is perhaps the best-characterized neuronal pathway
involved in the regulation of energy homeostasis. This collection of circuits is unique in …

Ghrelin, an endogenous ligand for the GH secretagogue receptor, was isolated from rat
stomach and is involved in a novel system for regulating GH release. Although previous …

Ghrelin is a hormone that stimulates growth hormone secretion and signals energy
insufficiency via interaction with its receptor, the growth hormone secretagogue receptor …

Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-
releasing activity. This activity is mediated by the activation of the so-called GH …

Background & Aims: Visceral sensory information is transmitted to the brain through the
afferent vagus nerve. Ghrelin, a peptide primarily produced in the stomach, stimulates both …