Subchondral bone structure has been observed to change in osteoarthritis (OA). However, it
remains unclear how the early-stage OA changes affect the mechanics (stresses and …

Cartilage defects resulting from injury or degeneration are a common clinical problem, and
due to its avascular nature, articular cartilage has poor self‐healing capacity. Three …

Most fractures in the third metacarpal bone of equine athletes occur due to repeated cycles
of high load magnitudes and are commonly generated during fast-training workouts. These …

Subchondral bone injury due to high magnitude and repetition of compressive loading is
common in humans and athletic animals such as Thoroughbred racehorses. Repeated …

Shape is a key factor in influencing mechanical responses of bones. Considered to be smart
viscoelastic and inhomogeneous materials, bones are stimulated to change shape (model …

Microdamage accumulation and adaptation of subchondral bone subjected to intensive
cyclic loading are important processes associated with catastrophic bone failure, and joint …

Subchondral bone (SCB) microdamage is commonly observed in traumatic joint injuries and
has been strongly associated with post-traumatic osteoarthritis (PTOA). Knowledge of the …

BACKGROUND: From childhood to adulthood, and to old age, the stiffness of calcified
cartilage zone increases gradually. But it is poorly understood that the effect of stiffness …

Lesions of the articular cartilage are frequent in all age populations and lead to functional
impairment. Multiple surgical techniques have failed to provide an effective method for …

Articular cartilage has limited self-healing capacity and damaged cartilage can lead to
osteoarthritis, and to the need for joint replacement surgery. Biomaterial based scaffolds …