Publisher Summary This chapter discusses the advances made in understanding the
mechanisms of action of chemical carcinogens in the light of the recent evidence that …

PURPOSE: Identification of prognostic factors is a primary basis for planning the treatment
and predicting the outcome of patients with colorectal cancer. Reviewing studies from the …

Ras family genes (H-, K-and N-ras) are implicated in a wide range of human rumours.
Mutations are a major activating mechanism for the ras family genes, mainly in codons 12 …

We examined a series of 29 surgical specimens of benign and malignant human prostate
tissue for the expression of both the cHa‐ras and c‐myc protooncogenes. Northern blots …

A partial complementary DNA was isolated for a gene (rrg) that is normally expressed in
mouse NIH 3T3 cells, but is down-regulated after cellular transformation by long terminal …

Advances in the field of oncogenes have produced a tool to investigate the different stages
in multistep carcinogenesis. The role of the ras and myc gene families have been …

Most people in the United States spend far more time indoors than outdoors. Yet, many air
pollution regulations and risk assessments focus on outdoor air. These often overlook …

The effects of expression of human c-myc and both mutated (T24) and normal forms of
human Ha-ras-1 were studied in an aneuploid rat fibroblast line (208F). Mutated T24 Ha-ras …

Metastasis, which is the spread of tumours throughout the body, is a pathophysiological
process of profound clinical significance. The relentless and intractable nature of metastatic …

The pattern of c‐myc gene organization and expression has been examined in resected
colonic tumors and in the adjacent normal colon from 15 patients undergoing radical …