Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …

Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female
reproductive tract causing high morbidity as they can significantly affect fertility and quality of …

The limited expandability of subcutaneous adipose tissue, due to reduced ability to recruit
and differentiate new adipocytes, prevents its buffering effect in obesity and is characterized …

Follistatin is a member of the TGF-β super family and inhibits the action of myostatin to
regulate skeletal muscle growth. The regulation of follistatin during physical exercise is …

Members of the TGF-β superfamily regulate many aspects of development, including
adipogenesis. Studies in cells and animal models have characterized the effects of …

The BMPs (bone morphogenetic proteins) and the GDFs (growth and differentiation factors)
together form a single family of cystine-knot cytokines, sharing the characteristic fold of the …

Context: Follistatin is a plasma protein recently reported to increase under conditions with
negative energy balance, such as exercise and fasting in humans. Currently, the perception …

Context: Wnt signaling regulates adipogenesis and adipocyte function. Secreted frizzled-
related proteins (SFRPs) are a family of secreted proteins (SFRP1-5) that bind and inhibit …

The bone morphogenetic proteins (BMPs) belong to the same superfamily as related to
transforming growth factor β (TGFβ), growth and differentiation factors (GDFs), and activins …

OBJECTIVE Growth of white adipose tissue takes place in normal development and in
obesity. A pool of adipose progenitors is responsible for the formation of new adipocytes and …