Gene regulatory network inference resources: A practical overview

D Mercatelli, L Scalambra, L Triboli, F Ray… - Biochimica et Biophysica …, 2020 - Elsevier
Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …

Inferring interaction networks from multi-omics data

JS Hawe, FJ Theis, M Heinig - Frontiers in genetics, 2019 - frontiersin.org
A major goal in systems biology is a comprehensive description of the entirety of all complex
interactions between different types of biomolecules—also referred to as the interactome …

PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants

J Jin, F Tian, DC Yang, YQ Meng, L Kong… - Nucleic acids …, 2016 - academic.oup.com
With the goal of providing a comprehensive, high-quality resource for both plant transcription
factors (TFs) and their regulatory interactions with target genes, we upgraded plant TF …

iTAK: a program for genome-wide prediction and classification of plant transcription factors, transcriptional regulators, and protein kinases

Y Zheng, C Jiao, H Sun, HG Rosli, MA Pombo, P Zhang… - Molecular plant, 2016 - cell.com
Transcription factors (TFs) are proteins that regulate the expression of target genes by
binding to specific cis-elements in promoter regions. Transcriptional regulators (TRs) also …

Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals

G Martín, Y Márquez, F Mantica, P Duque, M Irimia - Genome biology, 2021 - Springer
Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular
organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS …

PlantTFDB 3.0: a portal for the functional and evolutionary study of plant transcription factors

J Jin, H Zhang, L Kong, G Gao, J Luo - Nucleic acids research, 2014 - academic.oup.com
With the aim to provide a resource for functional and evolutionary study of plant transcription
factors (TFs), we updated the plant TF database PlantTFDB to version 3.0 (http://planttfdb …

PlantPAN 2.0: an update of plant promoter analysis navigator for reconstructing transcriptional regulatory networks in plants

CN Chow, HQ Zheng, NY Wu, CH Chien… - Nucleic acids …, 2016 - academic.oup.com
Transcription factors (TFs) are sequence-specific DNA-binding proteins acting as critical
regulators of gene expression. The Plant P romoter A nalysis N avigator (PlantPAN; …

Temporal transcriptome profiling reveals expression partitioning of homeologous genes contributing to heat and drought acclimation in wheat (Triticum aestivum L.)

Z Liu, M Xin, J Qin, H Peng, Z Ni, Y Yao, Q Sun - BMC plant biology, 2015 - Springer
Abstract Background Hexaploid wheat (Triticum aestivum) is a globally important crop. Heat,
drought and their combination dramatically reduce wheat yield and quality, but the …

ChIP-Hub provides an integrative platform for exploring plant regulome

LY Fu, T Zhu, X Zhou, R Yu, Z He, P Zhang… - Nature …, 2022 - nature.com
Plant genomes encode a complex and evolutionary diverse regulatory grammar that forms
the basis for most life on earth. A wealth of regulome and epigenome data have been …

Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

KN Chang, S Zhong, MT Weirauch, G Hon, M Pelizzola… - elife, 2013 - elifesciences.org
The gaseous plant hormone ethylene regulates a multitude of growth and developmental
processes. How the numerous growth control pathways are coordinated by the ethylene …