Purpose The role of the microenvironment during the initiation and progression of
carcinogenesis is now realized to be of critical importance, both for enhanced understanding …

Lysyl oxidase (LOX) family oxidases, LOX and LOXL1-4, oxidize lysine residues in
collagens and elastin, resulting in the covalent crosslinking and stabilization of these …

OBJECTIVE—Obesity is associated with endocrine abnormalities that predict the
progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been …

“Secretome” is referred to as the rich, complex set of molecules secreted from living cells. In
a less strict definition frequently followed in “secretome” studies, the term also includes …

S100 proteins are EF-hand calcium-binding proteins with various intracellular functions
including cell proliferation, differentiation, migration, and apoptosis. Some S100 proteins are …

Cancer is a leading cause of death. Early detection is usually associated with better clinical
outcomes. Recent advances in genomics and proteomics raised hopes that new biomarkers …

In the strictest sense, the cell secretome (conditioned media) refers to the collection of
proteins that contain a signal peptide and are processed via the endoplasmic reticulum and …

Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic
monitoring. However, currently available cancer biomarkers have the disadvantage of …

Bone is the one of the most common sites of distant metastasis of solid tumors. Secreted
proteins are known to influence pathological interactions between metastatic cancer cells …

The cell secretome is a collection of proteins consisting of transmembrane proteins (TM) and
proteins secreted by cells into the extracellular space. A significant portion (~ 13–20%) of the …