[HTML][HTML] An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
[HTML][HTML] How location and cellular signaling combine to activate the NLRP3 inflammasome
A Akbal, A Dernst, M Lovotti, MSJ Mangan… - Cellular & molecular …, 2022 - nature.com
Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …
[HTML][HTML] Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus
N Miao, Z Wang, Q Wang, H Xie, N Yang… - Nature …, 2023 - nature.com
Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in
systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from …
systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from …
[HTML][HTML] The NLRP3 inflammasome: contributions to inflammation-related diseases
Y Chen, X Ye, G Escames, W Lei, X Zhang, M Li… - Cellular & molecular …, 2023 - Springer
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …
innate immune responses by activating caspase-1 and the inflammatory cytokines …
[HTML][HTML] Complement membrane attack complex: new roles, mechanisms of action, and therapeutic targets
The complement membrane attack complex (MAC) is classically known as a cytolytic effector
of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or …
of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or …
The signaling pathways regulating NLRP3 inflammasome activation
M Chen, X Ye, X He, D Ouyang - Inflammation, 2021 - Springer
The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …
[HTML][HTML] The NLRP3–inflammasome as a sensor of organelle dysfunction
Diverse pathogen-and damage-associated stresses drive inflammation via activation of the
multimolecular NLRP3–inflammasome complex. How the effects of diverse stimuli are …
multimolecular NLRP3–inflammasome complex. How the effects of diverse stimuli are …
Cardiac allograft vasculopathy: current review and future research directions
JS Pober, S Chih, J Kobashigawa… - Cardiovascular …, 2021 - academic.oup.com
Cardiac allograft vasculopathy (CAV) is a pathologic immune-mediated remodelling of the
vasculature in transplanted hearts and, by impairing perfusion, is the major cause of late …
vasculature in transplanted hearts and, by impairing perfusion, is the major cause of late …
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling
pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that …
pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that …
Chlorogenic acid suppresses miR‐155 and ameliorates ulcerative colitis through the NF‐κB/NLRP3 inflammasome pathway
J Zeng, D Zhang, X Wan, Y Bai, C Yuan… - Molecular Nutrition & …, 2020 - Wiley Online Library
Scope The over‐activation of the nucleotide‐binding domain like receptor protein 3 (NLRP3)
inflammasome plays an important role in the pathogenesis of ulcerative colitis (UC) …
inflammasome plays an important role in the pathogenesis of ulcerative colitis (UC) …