The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Increasing evidences have shown strong associations between gut microbiota and many
human diseases, and understanding the dynamic crosstalks of host-microbe interaction in …

Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …

The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

Bats have emerged as unique mammalian vectors harboring a diverse range of highly lethal
zoonotic viruses with minimal clinical disease. Despite having sustained complete genomic …

Abstract cGAS is a sensor of cytosolic DNA and responds equally to exogenous and
endogenous DNA. After recognition of cytosolic dsDNA or ssDNA, cGAS synthesizes the …

Intracortical microelectrodes are a critical component of brain-machine interface (BMI)
systems. The recording performance of intracortical microelectrodes used for both basic …

Mouse p202 is a disease locus for lupus and a dominant‐negative inhibitor of AIM 2
inflammasome activation. A human homolog of p202 has not been identified so far. Here, we …

Background Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and
pyroptosis act as critical natural immune signaling axes for microbial infection, chronic …