Emerging Carbapenem-Resistant Enterobacteriaceae Infection, Its Epidemiology and Novel Treatment Options: A Review

M Tilahun, Y Kassa, A Gedefie… - Infection and drug …, 2021 - Taylor & Francis
Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …

Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design

G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

NDM metallo-β-lactamases and their bacterial producers in health care settings

W Wu, Y Feng, G Tang, F Qiao… - Clinical microbiology …, 2019 - Am Soc Microbiol
New Delhi metallo-β-lactamase (NDM) is a metallo-β-lactamase able to hydrolyze almost all
β-lactams. Twenty-four NDM variants have been identified in> 60 species of 11 bacterial …

Present and future of carbapenem-resistant Enterobacteriaceae infections

B Suay-García, MT Pérez-Gracia - Advances in clinical …, 2021 - taylorfrancis.com
This chapter analyzes the epidemiology of Carbapenem-Resistant Enterobacteriaceae
(CRE) as well as current and future treatment options against the increasingly resistant …

The global ascendency of OXA-48-type carbapenemases

JDD Pitout, G Peirano, MM Kock… - Clinical microbiology …, 2019 - Am Soc Microbiol
Surveillance studies have shown that OXA-48-like carbapenemases are the most common
carbapenemases in Enterobacterales in certain regions of the world and are being …

[HTML][HTML] Global spread of carbapenem-resistant Enterobacteriaceae: Epidemiological features, resistance mechanisms, detection and therapy

J Ma, X Song, M Li, Z Yu, W Cheng, Z Yu… - Microbiological …, 2023 - Elsevier
Bacterial drug resistance has become a global public health threat, among which the
infection of carbapenem-resistant Enterobacterales (CRE) is one of the top noticeable …

Phenotypic detection of carbapenemase-producing organisms from clinical isolates

PD Tamma, PJ Simner - Journal of clinical microbiology, 2018 - Am Soc Microbiol
The rapid spread of multidrug-resistant Gram-negative organisms constitutes one of the
greatest challenges to global health. While Gram-negative organisms have developed …

Plasmid evolution in carbapenemase‐producing Enterobacteriaceae: a review

K Kopotsa, J Osei Sekyere… - Annals of the New York …, 2019 - Wiley Online Library
Carbapenem‐resistant Enterobacteriaceae (CRE) have been listed by the WHO as high‐
priority pathogens owing to their high association with mortalities and morbidities …

Strategies for developing sensitive and specific nanoparticle-based lateral flow assays as point-of-care diagnostic device

JH Soh, HM Chan, JY Ying - Nano Today, 2020 - Elsevier
From a home-based pregnancy self-testing kit, lateral flow assays (LFAs) have proliferated
and gained widespread utilization as point-of-care (POC) test kits. Their prevalence is due to …

Detection of Multidrug-Resistant Enterobacterales—From ESBLs to Carbapenemases

J Noster, P Thelen, A Hamprecht - Antibiotics, 2021 - mdpi.com
Multidrug-resistant Enterobacterales (MDRE) are an emerging threat to global health,
leading to rising health care costs, morbidity and mortality. Multidrug-resistance is commonly …