Oxygen (O 2) toxicity remains a concern, particularly to the lung. This is mainly related to
excessive production of reactive oxygen species (ROS). Supplemental O 2, ie inspiratory O …

For half a century, we have known that some patients experience neurocognitive dysfunction
after cardiac surgery, yet defining its incidence, course, and causes remains challenging …

Postoperative delirium is a geriatric syndrome that manifests as changes in cognition,
attention, and levels of consciousness after surgery. It occurs in up to 50% of patients after …

Background Postoperative delirium (POD) is a common surgical complication associated
with increased morbidity and mortality in elderly. Although the underlying mechanisms …

Objective To examine whether supraphysiological oxygen administration during surgery is
associated with lower or higher postoperative kidney, heart, and lung injury. Design …

BACKGROUND: Despite evidence suggesting detrimental effects of perioperative
hyperoxia, hyperoxygenation remains commonplace in cardiac surgery. Hyperoxygenation …

Background Mechanisms of postoperative delirium remain poorly understood, limiting
development of effective treatments. We tested the hypothesis that intraoperative oxidative …

Objective Neuroimaging advances our understanding of delirium pathophysiology and its
consequences. A previous systematic review identified 12 studies (total participants N= 764 …

Purpose Although evidence from observational studies in a variety of clinical settings
supports the utility of cerebral oximetry as a predictor of outcomes, prospective clinical trials …

Postoperative delirium (POD) after cardiac surgery is a well-known phenomenon which
carries a higher risk of morbidity and mortality. Multiple patient-specific risk factors and …