Hydroxyurea is a well-established inhibitor of ribonucleotide reductase that has a long
history of scientific interest and clinical use for the treatment of neoplastic and non …

Cdc42p is an essential GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases.
These proteins act as molecular switches by responding to exogenous and/or endogenous …

For decades after the discovery that a contractile ring made of actin filaments and myosin II
produces the force to constrict the cleavage furrow of animal cells, the complexity of …

In Saccharomyces cerevisiae, the mother cell and bud are connected by a narrow neck. The
mechanism by which this neck is closed during cytokinesis has been unclear. Here we …

We have characterized a human homologue of anillin, a Drosophila actin binding protein.
Like Drosophila anillin, the human protein localizes to the nucleus during interphase, the …

The fission yeast Schizosaccharomyces pombe divides symmetrically using a medial F-actin–
based contractile ring to produce equal-sized daughter cells. Mutants defective in two …

Present in organisms ranging from yeast to man, homologues of the Drosophila Polo kinase
control multiple stages of cell division. At the onset of mitosis, Polo-like kinases (Plks) …

Schizosaccharomyces pombe is an excellent organism in which to study cytokinesis as it
divides by medial fission using an F-actin contractile ring. To enhance our understanding of …

Cytokinesis in Saccharomyces cerevisiae occurs by the concerted action of the actomyosin
system and septum formation. Here we report on the roles of HOF1, BNI1, and BNR1 in …

Saccharomyces cerevisiae chs2 mutants are unable to synthesize primary septum chitin,
and myo1 mutants cannot construct a functional contractile ring. The morphology of the two …