Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

Autophagy is a conserved intracellular pathway that delivers cytoplasmic contents to
lysosomes for degradation via double-membrane autophagosomes. Autophagy substrates …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Growth factors and nutrients enhance protein synthesis and suppress overall protein
degradation by activating the protein kinase mammalian target of rapamycin (mTOR) …

Defining the multiple roles of the mechanistic (formerly'mammalian') target of rapamycin
(mTOR) signalling pathway in neurological diseases has been an exciting and rapidly …

Mechanistic target of rapamycin (mTOR) functions as a key homeostatic regulator of cell
growth and orchestrates whether anabolic or catabolic reactions are favoured. mTOR …

The ability to maintain a functional proteome, or proteostasis, declines during the ageing
process. Damaged and misfolded proteins accumulate with age, impairing cell function and …

Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a …