Common side effects of opioid administration include sedation, dizziness, nausea, vomiting,
constipation, physical dependence, tolerance, and respiratory depression. Physical …

Delirium is the most common complication found in the general hospital setting. Yet, we
know relatively little about its actual pathophysiology. This article contains a summary of …

Poorly controlled pain is a global public health issue. The personal, familial and societal
costs are immeasurable. Only a minority of European patients have access to a …

Delirium is a neurobehavioral syndrome caused by the transient disruption of normal
neuronal activity secondary to systemic disturbances. It is also the most common psychiatric …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Pain is highly prevalent in patients with pancreas cancer and contributes to the morbidity of
the disease. Pain may be due to pancreatic enzyme insufficiency, obstruction, and/or a direct …

Background Placebos are widely used in clinical practice in spite of ethical restrictions.
Whether such use is justified depends in part on the relative benefit of placebos compared to …

Background: Although chronic pain affects around 20% of adults in Europe and the USA,
there is substantial evidence that it is inadequately treated. In June 2009, an international …

This review article offers an outlook on the use of opioids as therapeutics for treating several
diseases, including cancer and non-cancer pain, and focuses the analysis on the …

Methods: Literature searches were performed using PubMed, EBSCO, Cochrane Review,
and Google Scholar without publication date limits. Of 264,617 articles' titles screened and …