Arrhythmia-induced cardiomyopathy (AIC) is a potentially reversible condition in which left
ventricular dysfunction is induced or mediated by atrial or ventricular arrhythmias. Cellular …

The ryanodine receptor (RyR) c corresponds to the sarcoplasmic reticulum (SR) Ca2+
channel (Inui et al., 1987; Imagawa et al., 1987). Its structure and function have been …

Ca2+ transients measured in failing human ventricular myocytes exhibit reduced amplitude,
slowed relaxation, and blunted frequency dependence. In the companion article (O'Rourke …

Myocardial failure has been considered to be an irreversible and progressive process
characterized by ventricular enlargement, chamber geometric alterations, and diminished …

During the last decade there was accumulating evidence Ž. that alterations of excitation-
contraction EC coupling may play a critical role in the pathophysiology of myocardial failure …

We construct a detailed mathematical model for Ca 2+ regulation in the ventricular myocyte
that includes novel descriptions of subcellular mechanisms based on recent experimental …

Intracellular Ca2+-release channels on the sarcoplasmic reticulum of striated muscle
[ryanodine receptors (RyRs)] and on the endoplasmic reticulum of almost all types of cells …

The molecular basis of human heart failure is unknown. Alterations in calcium homeostasis
have been observed in failing human heart muscles. Intracellular calcium-release channels …

RASopathies are a family of developmental disorders that share germline mutations in the
components of the RAS-MAPK pathway leading to dysregulated signalling. A high …

Atrial fibrillation (AF) and heart failure (HF) are chronic cardiovascular conditions that
continue to increase in prevalence worldwide and have been described as global …