The genetic basis for adult onset glaucoma: recent advances and future directions
Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
The role of lysyl oxidase enzymes in cardiac function and remodeling
C Rodríguez, J Martínez-González - Cells, 2019 - mdpi.com
Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and
four LOX-like isoenzymes (LOXL1–4)) critical for extracellular matrix (ECM) homeostasis …
four LOX-like isoenzymes (LOXL1–4)) critical for extracellular matrix (ECM) homeostasis …
Pseudoexfoliation syndrome and glaucoma: from genes to disease mechanisms
U Schlötzer-Schrehardt, CC Khor - Current Opinion in …, 2021 - journals.lww.com
PEX-associated genes are beginning to reveal relevant biological pathways and processes
involved in disease development. To understand the functional consequences and …
involved in disease development. To understand the functional consequences and …
Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1
F Pasutto, M Zenkel, U Hoja, D Berner, S Uebe… - Nature …, 2017 - nature.com
Although lysyl oxidase-like 1 (LOXL1) is known as the principal genetic risk factor for
pseudoexfoliation (PEX) syndrome, a major cause of glaucoma and cardiovascular …
pseudoexfoliation (PEX) syndrome, a major cause of glaucoma and cardiovascular …
The role of lysyl oxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma
U Schlötzer-Schrehardt, M Zenkel - Experimental Eye Research, 2019 - Elsevier
Exfoliation syndrome (XFS) is an age-related systemic disease that affects the extracellular
matrix. It increases the risk of glaucoma (exfoliation glaucoma, XFG) and susceptibility to …
matrix. It increases the risk of glaucoma (exfoliation glaucoma, XFG) and susceptibility to …
Lysyl oxidase like 1: biological roles and regulation
Abstract Lysyl Oxidase Like 1 (LOXL1) is a gene that encodes for the LOXL1 enzyme. This
enzyme is required for elastin biogenesis and collagen cross-linking, polymerising …
enzyme is required for elastin biogenesis and collagen cross-linking, polymerising …
[HTML][HTML] Open angle glaucoma
N Mahabadi, LA Foris, K Tripathy - 2017 - europepmc.org
Objectives: Identify the risk factors for open-angle glaucoma. Explain how to diagnose open-
angle glaucoma. Summarize the treatment options available for patients with open-angle …
angle glaucoma. Summarize the treatment options available for patients with open-angle …
Risk for exfoliation syndrome in women with pelvic organ prolapse: a Utah Project on Exfoliation Syndrome (UPEXS) study
Importance Exfoliation syndrome, an inherited systemic disorder of elastin and extracellular
matrix (ECM), is associated with theLOXL1gene locus. Pelvic organ prolapse is a common …
matrix (ECM), is associated with theLOXL1gene locus. Pelvic organ prolapse is a common …
[HTML][HTML] Novel protein constituents of pathological ocular pseudoexfoliation syndrome deposits identified with mass spectrometry
S Sharma, T Chataway, S Klebe, K Griggs… - Molecular …, 2018 - ncbi.nlm.nih.gov
Purpose Pseudoexfoliation (PEX) syndrome is an age-related progressive disease of the
extracellular matrix with ocular manifestations. PEX is clinically diagnosed by the presence …
extracellular matrix with ocular manifestations. PEX is clinically diagnosed by the presence …
Platelet Proteome Reveals Novel Targets for Hypercoagulation in Pseudoexfoliation Syndrome
Pseudoexfoliation syndrome (PEX) is characterized by the accumulation of abnormal
extracellular matrix material in ocular and non-ocular tissues, including blood vessel walls …
extracellular matrix material in ocular and non-ocular tissues, including blood vessel walls …